Table 1.

Sensitivity of CSGE for detection of polymorphisms and mutations

Gene	Known polymorphisms and mutations		Heteroduplexes by CSGE (detected/assayed)
	Exon sequences	Intron sequences
COL1A1	18	22	40/40*
COL1A2	10	0	10/10
COL2A1	8	15	23/23
COL3A1	3	0	3/3
Totals	39	37	76/76

^*One single-base polymorphism in intron 21 of the COL1A1 gene was consistently detected with a PCR product spanning exon 22 but inconsistently detected with an overlapping PCR product spanning exon 21.