Table 1.
Characteristics of Several Animal Models of Acute Pancreatitis
| Model | Animal Species | Pancreatic Necrosis | Pancreatic Infection | Mortality | Invasiveness |
|---|---|---|---|---|---|
| Duodenal loop24,25 | Rat | No | Considerable | High | Laparotomy |
| Choline-deficient diet30–32 | Mouse | Yes | Little | High | Minimal |
| Duct ligation34–37 | Rat/opossum | No/Yes | Little | Low | Laparotomy |
| Cerulein44 | Mouse/rat | Yes/No | Little | Low | Minimal |
| Duct perfusion48 | Rat/dog/pig | Yes | Considerable | Moderate to high | Laparotomy |
| Duct perfusion + cerulein52 | Rat | Yes | Considerable | Moderate | Laparotomy |