Table 2.

Urinary and faecal recovery (0–168 h) of ixabepilone and total radioactivity in cancer patients after a 3 h intravenous infusion of 70 mg, 80 nCi [¹⁴C]ixabepilone

Nra	Recovery (% of dose)				Radioactivity (U/F ratioc)	Ixabepilone (Clrenal (l/h))
	Ixabepilone	Total radioactivity
	Urine	Urine	Faeces	Total
1	5.07	14.56	59.69	74.25	0.24	1.16
2	4.66	23.28	74.78	98.06	0.31	1.19
3	7.76	14.77	38.29	53.06	0.39	1.92
4	3.32	25.08	12.71	37.79	1.97	0.61
5	5.46	19.66	65.02	84.68	0.30	1.58
6	6.12	30.78	64.59	95.37	0.48	1.98
7	6.03	25.05	86.72	111.77	0.29	1.87
8	4.02	47.65	15.62	63.27	3.05	1.46
Mean	5.30	25.10	52.18	77.28	0.33b	1.47
SD	1.38	10.63	27.17	24.94	0.08b	0.47

^aPatients 1, 2, and 8 were male.

^bPatient 4 was not included because of the extremely low production of faeces and patient 8 was not included in the calculation because his bile duct obstruction (relevance illustrated by increasing plasma bilirubin concentrations) may have reduced faecal excretion.

^cThe U/F ratio is the ratio of urinary recovery relative to faecal recovery.