Table 4.
The ferroxidase center in PfFtn and its homologous crystallized ferritins
| PDB ID | Protein name | Source organism | Resolution (Å) | FC type | Metal site occupation |
|---|---|---|---|---|---|
| – | Ferritin | Pyrococcus furiosus | 2.75 | FtnA | A (Fe) A, B, C (Fe,Zn) |
| 1s3q | Ferritin | Archaeoglobus fulgidus | 2.10 | FtnA | A, B (Zn)a A, B, C (Fe) |
| 1vlg | Ferritin (TM1128) | Thermotoga maritima | 2.00 | FtnA | A (Fe) |
| 1krq | Ferritin | Campylobacter jejuni | 2.70 | FtnA | A, B (Ow?)b |
| 1eum | Ferritin ECFTNA | Escherichia coli | 2.05 | FtnA | A, B (Zn)c A, B, C (Fe) |
| 1r03 | Mitochondrial ferritin | Homo sapiens sapiens | 1.70 | HuHF | – |
| 2fha | H ferritin K86Q mutant | Homo sapiens sapiens | 1.90 | HuHF | – |
| 1mfr | M ferritin | Rana catesbeiana | 2.80 | HuHF | – |
| 1rcg | L ferritin | Rana catesbeiana | 2.20 | – | – |
FC ferroxidase center
aZn in 1s3q and Fe in 1sq3 [2]
b1krq contains four water molecules, two of which are located at the FC, in positions corresponding to A and B sites. They might be low-occupancy metal sites but there is no indication of whether it is a native or a soaked crystal
c1eum corresponds to the native structure [1]; these sites were located in the Zn2+ and Fe3+ derivatives, respectively, for which no coordinates were deposited in the PDB