Table 4.
Maternal spina bifida risk for the combination of the NOS3 894G>T SNP and elevated plasma homocysteine concentration, adjusted for age
| NOS3 894G>T | Plasma Hcy conc (μmol/L)a | Mothers (%) | Female controls (%) | OR (95%CI) |
|---|---|---|---|---|
| GG | <12.56 | 42 (36.8) | 100 (38.6) | 1b |
| GG | ≥12.56 | 7 (6.1) | 30 (11.6) | 0.66 (0.26–1.65) |
| GT/TT | <12.56 | 47 (41.2) | 108 (41.7) | 1.17 (0.69–1.96) |
| GT/TT | ≥12.56 | 18 (15.8) | 21 (8.1) | 3.38 (1.46–7.84) |
aThe 80th percentile of the control plasma homocysteine distribution was used to define elevated plasma homocysteine concentrations
bReference group