Fig. 2.

NOx in plasma and urine. NOx levels in plasma and urine were measured at various times after LPS⁻ (open bars, n = 3) or LPS⁺ (closed bars, n = 6) treatment or LPS⁺ together with aminoguanidine (gray bars, n = 6). a Blood samples show a peak concentration at 12 h and coadministration with aminoguanidine reversed this increase at both 6 and 12 h. b The urinary excretion of NOx increased 12 h after LPS⁺ treatment, and aminoguanidine returned this increase to baseline levels. Data are expressed as mean±SE. Significantly different compared to the LPS⁻ (single asterisksP < 0.05, double asterisksP < 0.01, triple asterisksP < 0.001) or LPS⁺ (double sharp signsP < 0.01, triple sharp signsP < 0.001)