Fig. 5.
mRNA expression of different renal ABC transporters. Gene expression of Abcb1a/P-gp (a) and Abcb1b/P-gp (b), Abcc2/Mrp2 (c), and Abcc4/Mrp4 (d) were determined in rat kidney at different time points after LPS− (open bars, n = 3) or LPS+ (closed bars, n = 6) treatment or LPS+ together with aminoguanidine (gray bars, n = 6). ΔCT values for the LPS−, given in Table 2, were set to 1. Data are expressed as mean±SE. Significantly different compared to the LPS− (single asterisks P < 0.05, double asterisks P < 0.01, triple asterisks P < 0.001) or LPS+ (sharp signs P < 0.05)