Table 1.

Renal functional parameters

Kidney function	Time (h)	Controls (LPS−)	LPS+	LPS+ and aminoguanidine
Total urine volume (ml)	3	1.6 ± 0.24	1.7 ± 0.27
	6	2.4 ± 0.65	4.45 ± 0.98	7.3 ± 0.76
	12	3.2 ± 0.57	10.0 ± 0.70a	9.4 ± 0.65a
	24	11.5 ± 0.25	13.7 ± 2.11
	48	23.5 ± 3.47	18.0 ± 1.57
BUN (mmol/l)	3	6.6 ± 0.20	9.9 ± 0.74
	6	4.6 ± 0.72	14.0 ± 1.48b	12.1 ± 0.82b
	12	6.3 ± 0.24	12.3 ± 1.38a	15.4 ± 1.27b
	24	7.0 ± 0.58	10.6 ± 0.58
	48	6.5 ± 0.10	9.1 ± 0.38
Blood creatinine (mmol/l)	3	0.035 ± 0.002	0.049 ± 0.002b
	6	0.039 ± 0.002	0.053 ± 0.002b	0.043 ± 0.019d
	12	0.037 ± 0.002	0.048 ± 0.002c	0.036 ± 0.032e
	24	0.038 ± 0.001	0.051 ± 0.001a
	48	0.042 ± 0.001	0.052 ± 0.001
Glucose excretion (μmol/h)	3	0.290 ± 0.045	0.481 ± 0.341
	6	0.333 ± 0.086	0.420 ± 0.100	0.478 ± 0.051
	12	0.425 ± 0.106	0.537 ± 0.054	0.332 ± 0.080
	24	0.254 ± 0.006	0.984 ± 0.039c
	48	0.325 ± 0.037	0.606 ± 0.128
Creatinine clearance (ml/min)	3	1.33 ± 0.12	0.78 ± 0.19
	6	1.06 ± 0.15	0.87 ± 0.09	0.93 ± 0.35
	12	1.01 ± 0.05	0.90 ± 0.03	1.01 ± 0.13
	24	1.19 ± 0.02	0.91 ± 0.20
	48	1.00 ± 0.07	1.08 ± 0.37
FENa (%)	3	0.816 ± 0.004	0.365 ± 0.073
	6	1.046 ± 0.145	0.358 ± 0.094b	1.423 ± 0.310e
	12	1.094 ± 0.097	0.458 ± 0.075a	1.610 ± 0.282e
	24	1.070 ± 0.024	0.429 ± 0.065c
	48	1.033 ± 0.077	0.121 ± 0.024a

Data are expressed as mean±SE, n = 6 for each time point for both LPS⁺ and LPS⁺ +aminoguanidine and n = 3 for LPS⁻

FE_Na fractional sodium excretion

^aSignificantly different compared to the control group; P < 0.01

^bSignificantly different compared to the control group; P < 0.001

^cSignificantly different compared to the control group; P < 0.05

^dSignificantly different compared to the LPS⁺ group; P < 0.01

^eSignificantly different compared to the LPS⁺ group; P < 0.001