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. 2007 Feb 7;454(2):321–334. doi: 10.1007/s00424-007-0210-x

Table 1.

Renal functional parameters

Kidney function Time (h) Controls (LPS) LPS+ LPS+ and aminoguanidine
Total urine volume (ml) 3 1.6 ± 0.24 1.7 ± 0.27
6 2.4 ± 0.65 4.45 ± 0.98 7.3 ± 0.76
12 3.2 ± 0.57 10.0 ± 0.70a 9.4 ± 0.65a
24 11.5 ± 0.25 13.7 ± 2.11
48 23.5 ± 3.47 18.0 ± 1.57
BUN (mmol/l) 3 6.6 ± 0.20 9.9 ± 0.74
6 4.6 ± 0.72 14.0 ± 1.48b 12.1 ± 0.82b
12 6.3 ± 0.24 12.3 ± 1.38a 15.4 ± 1.27b
24 7.0 ± 0.58 10.6 ± 0.58
48 6.5 ± 0.10 9.1 ± 0.38
Blood creatinine (mmol/l) 3 0.035 ± 0.002 0.049 ± 0.002b
6 0.039 ± 0.002 0.053 ± 0.002b 0.043 ± 0.019d
12 0.037 ± 0.002 0.048 ± 0.002c 0.036 ± 0.032e
24 0.038 ± 0.001 0.051 ± 0.001a
48 0.042 ± 0.001 0.052 ± 0.001
Glucose excretion (μmol/h) 3 0.290 ± 0.045 0.481 ± 0.341
6 0.333 ± 0.086 0.420 ± 0.100 0.478 ± 0.051
12 0.425 ± 0.106 0.537 ± 0.054 0.332 ± 0.080
24 0.254 ± 0.006 0.984 ± 0.039c
48 0.325 ± 0.037 0.606 ± 0.128
Creatinine clearance (ml/min) 3 1.33 ± 0.12 0.78 ± 0.19
6 1.06 ± 0.15 0.87 ± 0.09 0.93 ± 0.35
12 1.01 ± 0.05 0.90 ± 0.03 1.01 ± 0.13
24 1.19 ± 0.02 0.91 ± 0.20
48 1.00 ± 0.07 1.08 ± 0.37
FENa (%) 3 0.816 ± 0.004 0.365 ± 0.073
6 1.046 ± 0.145 0.358 ± 0.094b 1.423 ± 0.310e
12 1.094 ± 0.097 0.458 ± 0.075a 1.610 ± 0.282e
24 1.070 ± 0.024 0.429 ± 0.065c
48 1.033 ± 0.077 0.121 ± 0.024a

Data are expressed as mean±SE, n = 6 for each time point for both LPS+ and LPS+ +aminoguanidine and n = 3 for LPS

FENa fractional sodium excretion

aSignificantly different compared to the control group; P < 0.01

bSignificantly different compared to the control group; P < 0.001

cSignificantly different compared to the control group; P < 0.05

dSignificantly different compared to the LPS+ group; P < 0.01

eSignificantly different compared to the LPS+ group; P < 0.001