Table 3.
Parameter | Controls (n = 4) | LPS− (n = 4) | LPS+ (n = 6) |
---|---|---|---|
GFR (μl/min) | 350 ± 25 | 380 ± 17 | 290 ± 20a |
Diuresis (μl/min) | 18.6 ± 1.8 | 21.1 ± 1.3 | 17.4 ± 1.0 |
FRwater (%) | 94.7 ± 0.2 | 94.5 ± 0.3 | 92.7 ± 0.6a |
RPP (mmHg)b | 88.4 ± 1.5 | 84.5 ± 1.7 | 88.7 ± 1.0 |
Data are expressed as mean ± SE of four to six perfused kidney experiments over the period 25-115 min. Untreated rats served as controls for this model. Kidneys were perfused for 150 min as described in the “Materials and methods” section
aSignificantly different from perfused control kidney (P < 0.05)
bConstant flow during the experiments was 18 ± 0.5 ml/min
FR fractional reabsorption, RPP renal perfusion pressure