Figure 1.

(A) IR HIV peptide immunization induces both mucosal and systemic long-lasting immunity. In contrast, systemic immunization induces only systemic CTL. Closed squares show killing of P18IIIB-I10-pulsed targets and open diamonds show killing on unpulsed targets. (B) Induction of the mucosal and systemic CTL responses by different routes of immunization with synthetic peptide HIV vaccine. Killing of peptide-pulsed targets (▪) is compared with killing of unpulsed targets (□) at an effector-to-target ratio of 50:1. Similar results were obtained at ratios of 25 and 12.5:1. In both A and B, SEM of triplicate cultures were all<5% of the mean.