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. 1986 Apr;87(4):649–656. doi: 10.1111/j.1476-5381.1986.tb14581.x

Cardiac hypoxia and subsequent reoxygenation: sensitivity to L-arginine methylester.

C Baccaro, F Bennardini, G Dini, F Franconi, A Giotti, R Matucci, P Minuti
PMCID: PMC1916797  PMID: 3708203

Abstract

The effect of L-arginine methylester (L-Arg-Me) was studied in the isolated heart of the guinea-pig perfused with hypoxic substrate-free medium for 30 min and subsequently reoxygenated with normal saline solution for 30 min. The administration of L-Arg-Me in basal conditions decreases dose-dependently heart rate without any changes in the myocardial structure. On the other hand, the administration of L-Arg-Me (5-10 mM) decreases ventricular arrhythmias, especially during reoxygenation; in fact ventricular fibrillation is abolished. L-Arg-Me treatment increases the recovery of normal electrical and mechanical activity at the end of reoxygenation and reduces the increase in basal tone. Treatment with 10 mM L-Arg-Me decreases lactate dehydrogenase (LDH) release in the effluent and lysosomal fragility in cardiac tissue, while it does not influence calcium gain. L-Arginine (L-Arg) does not mimic any of the effects of L-Arg-Me.

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Selected References

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