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. 1986 Aug;88(4):815–820. doi: 10.1111/j.1476-5381.1986.tb16254.x

Investigation of the maternal to foetal serum concentration gradient of dexamethasone in the rat.

D R Varma
PMCID: PMC1917063  PMID: 3742160

Abstract

The basis of the maternal to foetal serum concentration gradient of dexamethasone was investigated in the rat on day 20 of gestation. The pregnant rat was assumed to behave as a two-compartment open model with one maternal and one foetal pool exchanging with each other and each to outside. Bolus injections of unlabelled dexamethasone were made into the mother and of [3H]-dexamethasone into its foetuses and serial maternal and foetal blood samples were collected a number of times. The monitoring of both forms of the drug in each sample permitted the estimation by a non-linear least square approach of two placental and two non-placental clearances. After both maternal and foetal injections of dexamethasone, its concentrations were higher in the maternal than in the foetal serum. Placental clearance of dexamethasone from the foetus to the mother was 824 +/- 40 ml kg-1 h-1 and 8.5 +/- 1 times greater than the placental clearance from the mother to foetus (103 +/- 2 ml kg-1 h-1). Foetal non-placental clearance was zero. It is suggested that a maternal to foetal serum gradient of dexamethasone is caused by its active transfer from the foetal to maternal side.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson D. F., Stock M. K., Rankin J. H. Placental transfer of dexamethasone in near-term sheep. J Dev Physiol. 1979 Dec;1(6):431–436. [PubMed] [Google Scholar]
  2. Anderson G. G., Rotchell Y., Kaiser D. G. Placental transfer of methylprednisolone following maternal intravenous administration. Am J Obstet Gynecol. 1981 Jul 15;140(6):699–701. doi: 10.1016/0002-9378(81)90207-6. [DOI] [PubMed] [Google Scholar]
  3. Ballard P. L., Granberg P., Ballard R. A. Glucocorticoid levels in maternal and cord serum after prenatal betamethasone therapy to prevent respiratory distress syndrome. J Clin Invest. 1975 Dec;56(6):1548–1554. doi: 10.1172/JCI108236. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bayard F., Louvet J. P., Ruckebusch Y., Boulard C. Transplacental passage of dexamethasone in sheep. J Endocrinol. 1972 Aug;54(2):349–350. doi: 10.1677/joe.0.0540349. [DOI] [PubMed] [Google Scholar]
  5. Blanford A. T., Murphy B. E. In vitro metabolism of prednisolone, dexamethasone, betamethasone, and cortisol by the human placenta. Am J Obstet Gynecol. 1977 Feb 1;127(3):264–267. doi: 10.1016/0002-9378(77)90466-5. [DOI] [PubMed] [Google Scholar]
  6. Duignan N. M., Andrews J., Williams J. D. Pharmacological studies with lincomycin in late pregnancy. Br Med J. 1973 Jul 14;3(5871):75–78. doi: 10.1136/bmj.3.5871.75. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Funkhouser J. D., Peevy K. J., Mockridge P. B., Hughes E. R. Distribution of dexamethasone between mother and fetus after maternal administration. Pediatr Res. 1978 Nov;12(11):1053–1056. doi: 10.1203/00006450-197811000-00005. [DOI] [PubMed] [Google Scholar]
  8. Ginsburg J. Placental drug transfer. Annu Rev Pharmacol. 1971;11:387–408. doi: 10.1146/annurev.pa.11.040171.002131. [DOI] [PubMed] [Google Scholar]
  9. Kream J., Mulay S., Fukushima D. K., Solomon S. Determination of plasma dexamethasone in the mother and the newborn after administration of the hormone in a clinical trial. J Clin Endocrinol Metab. 1983 Jan;56(1):127–133. doi: 10.1210/jcem-56-1-127. [DOI] [PubMed] [Google Scholar]
  10. McNay J. L., Dayton P. G. Placental transfer of a substituted pteridine from fetus to mother. Science. 1970 Feb 13;167(3920):988–990. doi: 10.1126/science.167.3920.988. [DOI] [PubMed] [Google Scholar]
  11. Mulay S., Varma D. R. Influence of streptozotocin-diabetes on the pharmacokinetics, placental transfer and tissue localization of dexamethasone in rats. Br J Pharmacol. 1984 Sep;83(1):139–144. doi: 10.1111/j.1476-5381.1984.tb10128.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Szeto H. H., Mann L. I., Bhakthavathsalan A., Liu M., Inturrisi C. E. Meperidine pharmacokinetics in the maternal-fetal unit. J Pharmacol Exp Ther. 1978 Aug;206(2):448–459. [PubMed] [Google Scholar]
  13. Szeto H. H. Pharmacokinetics in the ovine maternal-fetal unit. Annu Rev Pharmacol Toxicol. 1982;22:221–243. doi: 10.1146/annurev.pa.22.040182.001253. [DOI] [PubMed] [Google Scholar]
  14. Varma D. R., Mulay S. Anti-inflammatory and ulcerogenic effects and pharmacokinetics of dexamethasone in protein-deficient rats. J Pharmacol Exp Ther. 1980 Jul;214(1):197–202. [PubMed] [Google Scholar]
  15. Varma D. R., Ramakrishnan R. A rat model for the study of transplacental pharmacokinetics and its assessment with antipyrine and aminoisobutyric acid. J Pharmacol Methods. 1985 Aug;14(1):61–74. doi: 10.1016/0160-5402(85)90043-9. [DOI] [PubMed] [Google Scholar]
  16. Varma D. R., Yue T. L. Influence of protein-calorie malnutrition on the pharmacokinetics, placental transfer and tissue localization of dexamethasone in rats. Br J Pharmacol. 1984 Sep;83(1):131–137. doi: 10.1111/j.1476-5381.1984.tb10127.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

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