Figure 1.

Association is described as a function of distance from disease to marker locus in megabases and parameters, with ɛ reflecting the number of generations since the original mutation, M reflecting mono- or polyphyletic origin of the mutation, and L representing bias introduced by assuming at least one associated allele per marker. Curves illustrate the decline of association with distance for a range of values of ɛ assuming M = 0.75 and L = 0.1.