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. 1994 Mar;54(3):516–525.

Genetic Mapping of the BRCA1 Region on Chromosome 17q21

Hans Albertsen, Rosemarie Plaetke, Linda Ballard, Esther Fujimoto, Judith Connolly, Elizabeth Lawrence, Pilar Rodriguez, Margaret Robertson, Paige Bradley, Bruce Milner, David Fuhrman, Andy Marks, Robert Sargent, Peter Cartwright, Nori Matsunami, Ray White
PMCID: PMC1918118  PMID: 8116621

Abstract

Chromosome 17q21 harbors a gene (BRCA1) associated with a hereditary form of breast cancer. As a step toward identification of this gene itself we developed a number of simple-sequence-repeat (SSR) markers for chromosome 17 and constructed a high-resolution genetic map of a 40-cM region around 17q21. As part of this effort we captured genotypes from five of the markers by using an ABI sequencing instrument and stored them in a locally developed database, as a step toward automated genotyping. In addition, YACs that physically link some of the SSR markers were identified. The results provided by this study should facilitate physical mapping of the BRCA1 region and isolation of the BRCA1 gene.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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