Figure 6.
Stable AS expression of PTI-1 inhibits the tumorigenic potential of CREF-Trans 6:4 NMT cells. Athymic nude mice were injected with 1 × 106 CREF-Trans 6, CREF-Trans 6:4 NMT, 4 NMT-Vector, and clones of 4 NMT PTI-1 AS cells. Results are the average tumor size of four animals per experimental condition 3 weeks after injection. The majority of animals injected with 4 NMT PTI-1 AS clones remained tumor free for the duration of the assay, a minimum of 60 days. Similar results were obtained in two additional studies.