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Effect of recombinant sAPP on BrdUrd incorporation in TSH-stimulated FRTL-5 cells. To investigate the contribution of sAPP to the proliferative effect, FRTL-5 cells were incubated with the indicated concentrations of sAPP. Note that addition of 10 nM sAPP resulted in a 3.5-fold proliferative increase compared with controls. Higher concentrations (100 nM) of sAPP resulted in a decreased stimulatory effect.
