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Synthetic route to CP-91149. a, HCl-MeOH, 60 h, 23°C, then NaHCO3/H2O, 77%; b, 1.0 equiv. 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide HCl, 1.5 equiv. 1-hydroxybenzotriazole, dichloromethane, 23°C, 18 h, 100% crude; c, 2.0 equiv. NaOH, MeOH, H2O, 25°C, 2 h, 80%; d, as for b, but 1.1 equiv. dimethylamine HCl and 1.1 equiv. triethylamine in dimethylformamide, 18 h, 25°C, 62%.
