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Basal and IL-1 (5 ng/ml) − stimulated PGE2 concentrations (pg/ml) in media during HIT-T15 cell incubations in RMPI 1640 containing 0.2% FBS in absence and presence of NS-398 (0.01 mM)
| Hours | Control | IL-1 | NS-398 | IL-1 with NS-398 |
|---|---|---|---|---|
| 2 | 100 ± 5 | 240 ± 5** | <20 | <20 |
| 4 | 210 ± 80 | 320 ± 30* | <20 | <20 |
| 8 | 340 ± 30 | 380 ± 25* | <20 | <20 |
| 24 | 475 ± 120 | 870 ± 220** | <20 | <20 |
Levels greater than control ∗, P < .005; ∗∗, P < .0005. n = 4 experiments.
