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Growth of TC-1 tumor cells in VLP-vaccinated mice. The mean tumor area in the days following tumor challenge is shown for experiment 1 of Table 1. (A) Results from C57BL/6 mice immunized with L1/L2 or L1/L2-E7 VLPs are compared with results from mice injected with PBS (naive). (B) Results after L1/L2-E7 vaccination of C57BL/6 derived β2-microglobulin knockout (B2M KO), perforin knockout, MHC class II knockout, or NK cell-depleted C57BL/6 mice are shown.
