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. 2007 May 5;35(11):3535–3550. doi: 10.1093/nar/gkm195

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© 2007 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Clonogenic cell survival assays after UVC (4 J/m²), γ rays (1 Gy) or etoposide treatment (VP16; 1 μM for 1.5 h). Established long-term clones were seeded at 500 cells per 6-cm diameter-dish 24 h before treatment. Here, ∼14 days later, cells were fixed and stained. Each point represents the mean of two independent experiments; each experiment represents three culture dishes per point. SD are indicated. Age of cells at the time of the last clonogenic cell survival assay: Control (pBD650; day 238); XPC^KD cell cl.21(day 456); hHR23A^KD cl.7 (day 236); hHR23B^KD cl.9 (day 272); DNA PKcs^KD cl. 1 (day 365); XRCC4^KD cl.9 (day 205); Ligase IV^KD cl.3 (day 176); Ligase III^KD cl.11 (day 178); Rad51^KD cl.2 (day 193); Rad54^KD cl.5 (day 322); MRE11^KD cl.32 (day 177); Rad50^KD cl.1 (day 175); NBS1^KD cl.11 (day 176); ATM^KD cl.12 (day 302); ATR^KD cl.9 (day 196); Ogg1^KD cl.27 (day 232). Arrows indicate a striking point highlighting intolerance to DNA damage.