Figure 5.

Regulation of splicing by editing in GluR-B pre-mRNA. At the Q/R site, editing of the Q/R base and an intronic hotspot is required for efficient splicing. A double-stranded structure is potentially resolved at the Q/R site, while a splice repressor is inactivated at the intronic editing hotspot 2. The edited nucleotides are sufficient to stimulate splicing. Editing at the R/G site represses splicing and enhances proper alternative splicing. An edited nucleotide at the R/G site is sufficient to suppress splicing. ADAR binding is not required.