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. Author manuscript; available in PMC: 2007 Jul 16.
Published in final edited form as: Invest Ophthalmol Vis Sci. 2007 Feb;48(2):652–660. doi: 10.1167/iovs.06-1007

Figure 2.

Figure 2

Inhibition of UV irradiation–induced JNK activation by caffeine. (A) Time course of UV irradiation–induced JNK phosphorylation. (B) Inhibition of UV irradiation–induced JNK phosphorylation by caffeine in a dose-dependent pattern. (C) Time course of UV irradiation–induced kinase activity of JNK. (D) Dose-dependent suppression of UV irradiation–induced kinase activity of JNK. HCE cells were lysed and JNK phosphorylation and kinase activities were detected by Western blot using specific anti-phospho-JNK antibodies or by immunocomplex kinase assay using the fusion protein ATF-2 as a substrate.