Table 1.
Transplant-related data of patients
| Parameter | Patients | |||
| Patient number and gender | #1, female | #2, male | #3, female | #4, female |
| Patient origin | Muenster | Muenster | Muenster | Hamburg |
| Age at SCT | 3 years | 3 years | 2 years | 21 years |
| Preparative regimen | Bu/Cy | Bu/Cy/ATG | Bu/Cy | Bu/Cy/ATG |
| Stem cell source and dose (no T-cell depletion) | BM (MRD), 11.3 × 106 CD34 | PBSC (MUD), 25 × 106 CD34 | BM (MRD), 5.6 × 106 CD34 | BM (MRD), 4.2 × 106 CD34 |
| GvHD prophylaxis | CsA, MTX | CsA, MTX | CsA, MTX | CsA, MTX |
| Neutrophil engraftment | day +14 | day +12 | day +18 | day +14 |
| Acute/chronic GvHD | grade II of gut/none | grade I of gut/none | grade II of skin/none | none |
| Therapy of acute/chronic GvHD | steroids/none | steroids/none | steroids + tacrolimus/none | none |
| Infections | Clostridium difficile enteritis, bacteremia with Staphylococci | CMV reactivation | CMV colitis | none |
| Toxicities | CsA-neurotoxicity | None | CsA-neurotoxicity | suspected VOD |
| Current donor cell chimerism | 91% | 95% | 90% | 99% |