Fig. 1.

Angiogenic synergism and vessel stability promoted by various members of the PDGF family alone or in combinations with FGF-2. Micropellets containing FGF-2 (A), PDGF-AA (B), PDGF-AB (C), PDGF-BB (D), PDGF-AA/FGF-2 (E and I), PDGF-AB/FGF-2 (F and J), or PDGF-BB/FGF-2 (G and K) together with the slow-release polymer sucrose aluminum octosulfate were implanted into the corneal micropockets of mice. Corneal neovascularization was examined on days 5 (A–H) and 70 (I–K) after growth factor implantation. The corneal neovascularization was quantitatively measured as clock hours and vessel lengths, and vascularization areas were calculated (H and L). Asterisks indicate the implanted pellets.