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Adenosine and ATP release during ischaemia persists in presence of TTX. TTX applied at 1 μmol/L rapidly blocks synaptic transmission (and in this case causes a fall in the Ado/ino tone). Although the AD is greatly delayed (vertical dashed line) ATP release still occurs following this event. Adenosine release is unaffected by the presence of TTX. Black bar denotes period of ischaemia.
