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. Author manuscript; available in PMC: 2008 Apr 30.
Published in final edited form as: Clin Dermatol. 2007;25(3):267–275. doi: 10.1016/j.clindermatol.2007.03.005

Figure 1.

Figure 1

Proposed model for development of sarcoidosis. Individuals inherit a spectrum of genetic polymorphisms that may influence susceptibility to disease, but that are only realized in the context of a relevant exposure. Disease-associated susceptibility genes may influence position on this matrix differentially, depending on the function of the individual gene product, and on the influence of gene-gene interactions. The relevance of environmental exposures may be influenced by their duration, intensity, timing or context. A similar model might also describe disease phenotype.