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. Author manuscript; available in PMC: 2008 Apr 30.
Published in final edited form as: Clin Dermatol. 2007;25(3):267–275. doi: 10.1016/j.clindermatol.2007.03.005

Figure 2.

Figure 2

Figure 2

Theoretical gene-environment relationships. Panels A and B depict diseases influenced only by the gene or environmental variable, while Panel C demonstrates an additive relationship for a dominant mutation “a” with environmental exposure modeled as a continuous variable. Panel D, a true (biologic) gene-environment interaction, where the effect of the genotype is variably influenced by the exposure. Modified from [18].