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Summary of evidence for environmental and genetic etiologies
| Environmental |
| Case clustering |
| Transmission via solid organ or stem cell transplant |
| Case-control association studies (e.g. ACCESS) |
| Analogy to chronic beryllium disease |
| Molecular analysis (micro-organism nucleic acids or proteins) |
| Genetic |
| Familial aggregation |
| Ethnic susceptibility |
| Case-control association studies |
| Non-parametric studies (e.g. genome scans) |
