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. Author manuscript; available in PMC: 2007 Jul 17.
Published in final edited form as: Neurobiol Dis. 2007 Jan 25;26(2):312–322. doi: 10.1016/j.nbd.2006.12.021

Figure 3. Nigral dopaminergic neurons in parkin knockout mice do not show increased sensitivity to subacute MPTP intoxication.

Figure 3

Stereological neuronal counts of TH-immunopositive and total (i.e. Nissl-positive) neurons in wild-type and parkin knockout mice were analyzed 2 weeks following a subacute paradigm of either saline or MPTP injections (25mg MPTP/kg for 5 days) in 3-month-old mice. While MPTP treatment causes a significant reduction in TH-immunopositive and total neurons, no significant differences in neuronal counts are observed between wild-type and parkin knockout mice receiving same amount of MPTP. Data represent mean ± SEM. *p< 0.05, statistical significance versus saline controls using ANOVA followed by Student-Newman-Keuls test, n=5–6 per group, n.s not significant.