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. Author manuscript; available in PMC: 2007 Jul 17.
Published in final edited form as: Neurobiol Dis. 2007 Jan 25;26(2):312–322. doi: 10.1016/j.nbd.2006.12.021

Figure 4. Nigral dopaminergic neurons in parkin knockout mice do not show abnormally increased sensitivity to acute MPTP intoxication with an increase in age.

Figure 4

Stereological neuronal counts of TH-immunopositive and total (i.e. Nissl-positive) neurons in wild-type and parkin knockout mice, 2 weeks following an acute paradigm of either saline or MPTP injections in (A) 3-month-old mice (15mg MPTP/kg four times, every 2h), and (B) 12–month-old mice (12.5mg MPTP/kg four times, every 2h). While MPTP treatment causes a significant reduction in TH-immunopositive and total neurons, no significant differences in neuronal counts are observed between wild-type and parkin knockout mice receiving the same amount of MPTP. Data represent mean ± SEM. *p< 0.05, statistical significance versus saline controls using ANOVA followed by Student-Newman-Keuls test, n=5–6 per group, n.s not significant.