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. Author manuscript; available in PMC: 2007 Jul 17.
Published in final edited form as: Neurobiol Dis. 2007 Jan 25;26(2):312–322. doi: 10.1016/j.nbd.2006.12.021

Figure 5. Nigral dopaminergic neurons in parkin knockout mice do not show increased sensitivity to chronic continuous infusion of MPTP.

Figure 5

Three-month-old male wild-type and parkin knockout mice were subjected to a chronic continuous exposure of either saline or MPTP (20mg MPTP/kg/day for 28 days). Analysis was performed 7 days after the end of the 28-day-period of MPTP infusion. (A) TH immunostainings in wild-type and parkin knockout mice show significant loss in TH staining after MPTP. No significant differences are observed between wild-type and parkin knockout mice receiving the same treatment (saline or MPTP) (Scale bar= 200μm). (B) Stereological neuronal counts of TH-immunopositive and total (i.e. Nissl-positive) neurons in wild-type and parkin knockout mice. While MPTP treatment causes a significant loss of TH-immunopositive and total neurons, no significant differences in neuronal counts are observed between wild-type and parkin knockout mice receiving the same treatment (saline or MPTP). Data represent mean ± SEM. *p< 0.05, statistical significance versus saline controls using ANOVA followed by Student-Newman-Keuls test, n=5–6 per group, n.s not significant.