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. Author manuscript; available in PMC: 2007 Jul 17.
Published in final edited form as: Neurobiol Dis. 2007 Jan 25;26(2):312–322. doi: 10.1016/j.nbd.2006.12.021

Figure 6. Alpha-synuclein accumulates in both wild-type and parkin knockout mice after chronic infusion of MPTP.

Figure 6

Alpha-synuclein-immunostaining was performed 7 days after the end of the 28-day-period of chronic continuous MPTP infusion. (A) SNpc of wild-type as well as parkin knockout mice shows significant accumulation of alpha synuclein induced by MPTP treatment. No significant differences are observed between wild-type and parkin knockout mice receiving same treatment (saline or MPTP) (Scale bar= 200μm). (B) High magnification image shows no difference between wildtype and parkin knockout mice following MPTP (Scale bar= 10 μm).