. Author manuscript; available in PMC: 2007 Jul 17.

Published in final edited form as: Neurobiol Dis. 2007 Jan 25;26(2):312–322. doi: 10.1016/j.nbd.2006.12.021

Table 1.

Stereological analysis of TH-positive neurons in Locus coeruleus (LC) of wild-type and parkin knockout mice treated with either saline and/or chronic continuous MPTP 20 mg/kg/day for 28 days and analyzed one week after chronic continuous administration of MPTP. Data are expressed as mean (n=5–9) ± SEM, and as ratio of the respective mean to wild type saline controls mean in percent. Statistical analysis was performed by ANOVA, revealing no significant differences among group means. Statistically significant differences in parkin knockout saline controls (*p<0.01) and in parkin knockout MPTP (*p<0.01) were observed compared to wild type saline controls.

Genotypes/Treatment	TH+ neurons of LC
Genotypes/Treatment	Cell counts	[%]
WT Saline	1250 ± 55.8	100.0
KO Saline	949.1 ± 51.4**	75.9
WT MPTP (20mg/kg/d)	1230 ± 61.8	98.4
KO MPTP (20mg/kg/d)	950.4 ± 55.37**	76.0