Figure 1.

MP2C suppresses pheromone-induced cell cycle arrest and projection formation. The diploid strain GA2201 (17) was transformed with pYES, pYES-MP2C, and pYES-cycMs3. Yeast cells grow normally in the absence of pheromone (− pheromone) but show cell cycle arrest and projection formation in its presence (+ pheromone). Cells expressing MP2C grow normally in the absence and presence of pheromone. In contrast, GA2201 cells, expressing the cycMs3 cyclin, grow normally in the absence of pheromone, but addition of pheromone induces projection formation but not cell cycle arrest.