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. 1992 Sep;36(9):1890–1893. doi: 10.1128/aac.36.9.1890

Mechanism of action of the antiherpesvirus biflavone ginkgetin.

K Hayashi 1, T Hayashi 1, N Morita 1
PMCID: PMC192205  PMID: 1329635

Abstract

Screening of plant extracts found that a biflavone from Cephalotaxus drupacea, which was found to be ginkgetin, is active against herpes simplex virus type 1 (HSV-1). This compound caused dose-dependent inhibition of virus replication with a 50% cytotoxic activity at 12.8 micrograms/ml and 50% anti-HSV-1 activity at 0.91 micrograms/ml, the therapeutic index being 14.1. Ginkgetin also showed inhibitory effects against HSV type 2 and human cytomegalovirus with therapeutic indices of 13.8 and 11.6, respectively. Ginkgetin had a weak virucidal activity against HSV-1 at more than 5 micrograms/ml. Both adsorption of HSV-1 to host cells and virus penetration into cells were unaffected by this agent. Ginkgetin suppressed viral protein synthesis when added at various steps of HSV-1 replication and exerted strong inhibition of transcription of the immediate-early genes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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