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Mutation of putative IL-2 core promoter elements. The sequence of the nontemplate strand of the −44 to +8 region of the IL-2 promoter is shown. Positions that match the consensus sequences for the TATA box, BREd, and Inr are indicated in bold. Mutations generated in these elements are indicated above the sequence. Mutants were transfected into Jurkat cells and stimulated luciferase activities were normalized to that observed with the wild type construct (indicated by the dashed line).
