Figure 1. Accumulation of lipid in the peripheral tissues of LXRα^–/–apoE^–/– mice.

(A) apoE^–/– and LXRα^–/–apoE^–/– mice at 34 weeks of age; the double-knockout mouse exhibits marked skin thickening and alopecia. (B and C) Histological analysis of tissues from representative apoE^–/– and LXRα^–/–apoE^–/– mice at 34 weeks of age. There was increased lipid accumulation in the tissues from the double-knockout mice as revealed by H&E (B) and oil red O (C) staining. Original magnification is as indicated. (D) Lipid accumulation in the skin occurs primarily in macrophages as revealed by oil red O and CD68 costaining.