Fig. 3.
Loss of BRCA1 induces genomic instability. (A and B) Array-CGH profiles of representative mammary tumors from K14cre;p53F/F and K14cre;Brca1F/F;p53F/F mice, respectively. Log2 hybridization ratios are plotted for 2,803 BAC clones, represented on the CGH microarray, at their genomic position. Red dots represent amplifications >0, and green dots represent deletions <0 (Rosetta error model; P < 0.01). (C) Comparison of array-CGH profiles of tumors from K14cre;Brca1F/F;p53F/F (n = 26) and K14cre;p53F/F (n = 27) mice shows that BRCA1 loss results in a significant increase of CNAs. Depicted are mean percentages of BACs with a P < 0.01 per tumor group and per chromosome. Statistical significance of the observed differences in percentage of CNAs between both groups was calculated using a two-sided t test (P = 0.00013).