Fig. 6.

Cross-species comparison of mouse and human BRCA1-deficient breast cancers. Unsupervised hierarchical clustering was used to compare gene expression profiles of human breast cancer samples from 16 BRCA1 mutation carriers (pink) and 28 sporadic ER-negative cases (gray), with profiles of 32 mammary tumors from K14cre;Brca1^F/F;p53^F/F female mice (orange) and 21 tumors from K14cre;p53^F/F female mice (blue). Most mouse Brca1^Δ/Δ;p53^Δ/Δ and human BRCA1-mutated tumors (42 of 48) are interspersed and cluster together in a single branch of the dendrogram. The complete heat map of all 5,410 significant genes is shown in SI Fig. 10.