Fig. 3.

Electrostatic potential and location of mutations in the structure of the ADD domain. (a) Surface electrostatic potential of the ADD domain, shown in the same orientation as the ribbon view in b. The helix in the GATA-like finger (h1) is solvent-exposed and basic, and the two helices within loop 2 of the PHD finger (h2 and h3) form another basic patch. The linker between the GATA-like and PHD fingers is highly acidic. (b) Ribbon structure of the ADD domain showing the locations of mutations found in patients with ATR-X syndrome. Mutations are classified as surface (green), buried (blue), or cysteine (orange) and are represented by using their side chains, except for the glycine mutation G249C/D and the glutamine insertion, which are represented by thickening the backbone. The surface mutations are individually labeled.