Skip to main content
. 2007 Jul 9;104(29):12181–12186. doi: 10.1073/pnas.0608891104

Fig. 1.

Fig. 1.

MF short-term synaptic plasticity is impaired in GluR7−/− mice. (a) PPF was found to be significantly reduced in GluR7−/− mice for short ISIs. (Left) Representative traces of averaged MF-EPSCs evoked by paired stimuli delivered at intervals of 20, 40, and 200 ms for WT and GluR7−/− mice. [Scale, 60 pA for WT and 50 pA for GluR7−/− (50 ms).] (Right) Summary graph of paired-pulse ratios at intervals ranging from 10 to 200 ms. ∗∗, P < 0.01; ∗∗∗, P < 0.001. (b) LFF, recorded when increasing the stimulation frequency from a basal value of 0.1 Hz, was also much reduced in GluR7−/− mice. (Left) Representative traces of averaged MF-EPSCs at stimulation frequencies of 0.1–3 Hz for WT and GluR7−/− mice. [Scale, 100 pA for WT and 50 pA for GluR7−/− (25 ms).] (Right) Summary graph of MF-EPSC amplitudes for stimulation frequencies of 0.2–3 Hz normalized to the amplitude of the responses at 0.1 Hz. ∗, P < 0.05; ∗∗∗, P < 0.001.