Table 2.

Criteria for the Diagnosis of Neurosarcoidosis

Definite

Clinical presentation compatible with neurosarcoidosis

Exclusion of other possible causes

Positive nervous system histology

Probable

Clinical presentation compatible with neurosarcoidosis

Laboratory support of CNS inflammation*

Exclusion of other possible causes

Evidence of systemic sarcoidosis†

Possible

Clinical presentation compatible with neurosarcoidosis

Exclusion of other possible causes

^*High concentration of CSF protein and high numbers of cells, the presence of oligoclonal bands, or MRI evidence compatible with neurosarcoidosis.

^†Positive histology or at least 2 indirect indicators from gallium scan, chest imaging, and serum angiotensin-converting-enzyme. Reproduced with permission from Oxford University Press.¹⁶

CNS, central nervous system; CSF, cerebrospinal fluid; MRI, magnetic resonance imaging