Fig. 3.

4.1B^−/− mice develop aggressive adenocarcinomas in a spontaneous tumor model of prostate cancer. (A) Western blotting for 4.1B (Upper) or 4.1G (Lower) in brain or prostate tissues shows that 4.1B is specifically lost in knockout animals. (B) 4.1B^−/−;TRAMP mice more commonly developed a variety of palpable, high-grade carcinomas in the prostate (arrows), including (starting from Upper Left and proceeding clockwise) compound, multilobed carcinomas; ventral-lobed carcinomas; anterior-lobed carcinomas; and dorsal-lobed carcinomas. These results are tabulated in Table 1.