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Bcl-2 is necessary for the CNF1-induced cell-survival. Graphs showing the percentage (±SD) of apoptotic cells after silencing of Bcl-2 (A) or Bcl-XL (B) proteins. (A) Transfection with Bcl-2 siRNA significantly reduces the effect of CNF1 against UVB-induced apoptosis. (B) Transfection with Bcl-XL siRNA does not influence the antiapoptotic activity of CNF1. Silencing of Bcl-2 and Bcl-XL was confirmed by Western blot analysis (right).
