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. 2007 Jul;18(7):2735–2744. doi: 10.1091/mbc.E06-10-0910

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© 2007 by The American Society for Cell Biology

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Figure 7. — CNF1-induced mitochondria alteration depends on the Rac1/PI3K/Akt/IKK pathway and Bcl-2 up-regulation. (A) Graph showing the average length (±SD) of mitochondria after inhibition of the Rac1/PI3K/Akt/IKK pathway before CNF1 exposure. (B) Confocal microscopy analysis of cells transfected with siBcl-2 before CNF1 exposure for 24 h and stained for mitochondria. (C) Graph showing the average length (±SD) of mitochondria after silencing of Bcl-2 before CNF1 exposure. CNF1 induces an increase in mitochondrial length via activation of the Rac1/PI3K/Akt/IKK pathway and increase in Bcl-2 proteins.

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