Figure 8.

Interaction and mutant phenotype analyses support a role for Trs65/Kre11 in three different cellular processes. Mutant phenotypes together with genetic and physical interactions suggest a role for Trs65/Kre11 in intracellular trafficking, cell wall biogenesis, and stress response. References for trs65Δ mutant phenotypes are 1) TRAPP function (this study); 2) cell wall biogenesis (Brown et al., 1993); and 3) oxidative-stress response, Prophecy (Fernandez-Ricaud et al., 2007) (Supplemental Table S3). 4) Genetic and physical interactions for Trs65 are detailed in this study or in SGD (Ball et al., 2000) and BioGrid (Stark et al., 2006), and they are summarized in Table 1 and Supplemental Table S2.