Figure 1.

Mouse line Tg(msd/Dll1)Ieg exhibits a transgenic external and internal phenotype. (A) Scheme of the Tg(msd/Dll1)Ieg transgene vector. (B-C) External phenotype of transgenic mice of (B) line Tg(msd/Dll1)1Ieg and (C) line Tg(msd/Dll1)2Ieg. Both lines show kinked tails and reduced axial length. Skeletal preparations of (D) transgenic and (E) wild-type mice stained with alizarin red and alcian blue. Although the body length is reduced in transgenic mice compared to wild-type littermates, the number of vertebral elements from the first cervical to the first sacral vertebral element remains unchanged.