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. 2007 Jul 20;3(7):e98. doi: 10.1371/journal.ppat.0030098

Figure 6. Proposed Model Displaying the Regulation of the SV40 Lytic Cycle.

Figure 6

VP1 is synthesized first, forming pentamers that sequester newly synthesized VP2 and VP3 (steps A–C). Virion assembly (step D) and the stoichiometry of five VP1 per VP2/3 prevent VP2 and VP3 particle incorporation (step E). VP4 is synthesized, it oligomerizes with VP3, and possibly VP2, and targets to the host cell membrane to form a pore (step F), which then initiates the lytic death of the host cell and the release of the progeny (step G).