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Time course of the aminoacylation of three variants of the ribozyme. The 3′extensions (from 5′ to 3′) are: GUUACG (squares), GUUUUACG (triangles), and GUUUUUUACG (circles). The curves show the nonlinear least-square fits of the equation f product = 1−exp{(k 2nd A 0/k Val-AMP)[exp(−k Val-AMP t)−1]}. The bar at 30 min corresponds to the time point where f product was established for all variants, which serves as the basis for comparison in this paper.
