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Circular dichroism (CD) spectra of duplex G2 19 bp (16 ——) and siRNA duplexes modified at the central domain changing the duplex structure sG2/aD10 (7 ·········), sG2/aW9 (10 – – –), and sG2/aW9s2U10 (11 −··−··−). Reagents and conditions: 10 mM Tris-HCl, 100 mM NaCl, and 10 mM MgCl2 buffer (pH 7.4), Temp. 25°C, duplexes concentration = 1 μM. Sequences of the corresponding duplexes are given in Table 1.
